Global Motilin Receptor Agonists Pipeline Insights Review 2015

. Professional Pack-40 () without prescription DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/lcrs5p/motilin_receptor) has announced the addition of the "Motilin Receptor Agonists -Pipeline Insights" report to their offering. Motilin Receptor Agonists Pipeline Insights provides the in-depth analysis of the pipeline assets across the Motilin Receptor Agonists. Buy Barley Grass online Spiriva (Tiotropium Bromide) without prescription The main objective of this report to track competitor pipeline molecules, related research activities, technology, collaborations, in-licensing and out-licensing deals. http://web-md.blogspot.com Buy Differin (Adapalen) with no Rx The Motilin Receptor Agonists Report helps to identify emerging players with potentially strong product information and create effective counter-strategies to gain competitive advantage. Motilin Receptor Agonists Pipeline Insights Report covers the Motilin Receptor Agonists pipeline molecules at various stages of development like Pre-registration phase, clinical phases (Phase III, Phase II & Phase I), pre-clinical and discovery phases. About Trecator-SC (Ethionamide) with free Rx The Report also provides Motilin Receptor Agonists related therapeutic assessments by molecule type, route of administration, monotherapy and combination products. Encorate with free Rx The Report also highlights the discontinued and inactive projects in pipeline for Motilin Receptor Agonists. Key Topics Covered: Motilin Receptor Agonists Overview Motilin Receptor Agonists Disease Associated Motilin Receptor Agonists Pipeline Therapeutics Motilin Receptor Agonists Therapeutics under Development by Companies Motilin Receptor Agonists Late Stage Products (Filed and Phase III) Comparative Analysis Motilin Receptor Agonists Mid Clinical Stage Products (Phase II) Comparative Analysis Motilin Receptor Agonists Early Clinical Stage Products (Phase I and IND Filed) Comparative Analysis Motilin Receptor Agonists Discovery and Pre-Clinical Stage Products Comparative Analysis Drug Candidate Profiles Motilin Receptor Agonists - Therapeutics Assessment Assessment by Monotherapy Products Assessment by Combination Products Assessment by Route of Administration Assessment by Molecule Type Motilin Receptor Agonists - Discontinued Products Motilin Receptor Agonists - Dormant Products Companies Involved in Therapeutics Development for Motilin Receptor Agonists Appendix For more information visit .researchandmarkets.com/research/lcrs5p/motilin_receptor

Astex Pharmaceuticals Announces Publication of Key Clinical Data for Guadecitabine (SGI-110) in The Lancet Oncology

PLEASANTON, Calif.--(BUSINESS WIRE)--Astex Pharmaceuticals, a pharmaceutical company dedicated to the discovery and development of novel small molecule therapeutics, announces the publication of key clinical data for the novel hypomethylating agent (HMA) guadecitabine (SGI-110) in the prestigious journal, The Lancet Oncology. Buy Rhinocort (Budesonide) The publication, entitled “Pharmacokinetic and Pharmacodynamic-guided Phase 1 study of the novel hypomethylating drug guadecitabine (SGI-110) in myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML)”, was released online on August 18, 2015 at .thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00038-8/abstract. The publication describes the first-in-human clinical trial of 93 heavily pre-treated patients (74 AML and 19 MDS) treated with guadecitabine and reports that the drug is well-tolerated, easily administered, and biologically and clinically active in both MDS and AML patients who relapsed after standard of care. Eldepryl (Selegiline) with free prescription Importantly, potent dose-related DNA demethylation is associated with clinical responses in patients treated with guadecitabine, with responders showing significantly more demethylation than non-responders. Buy Amoxil (Amoxicillin) without prescription The study was conducted at 13 leading cancer centers in the US and Canada. The results described in this publication were used to inform the design of a large Phase 2 study in both treatment na"ive and relapsed / refractory AML and MDS, in which over 300 patients were treated with guadecitabine, and a recently-commenced 800-patient global Phase 3 study (ASTRAL-1), in which guadecitabine is being compared with physician’s choice of decitabine, azacitidine, or low-dose cytarabine in treatment na"ive AML patients unfit to receive, or unsuitable for, intensive induction chemotherapy. Lead Author, Jean-Pierre Issa, MD of Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine said, “This study demonstrates that guadecitabine is safe, and showed that the drug resulted in improved PK exposure and PD demethylation over what has been reported for the first-generation HMAs. Buy Elestat with no prescription It also confirmed the importance of DNA demethylation as a PD marker for clinical response." Dr. About Requip (Ropinirole) without Rx Issa added, “Guadecitabine’s improved PK and PD profile may improve clinical outcomes in patients with hematologic malignancies, and may also make the drug useful in the treatment of solid tumors, an area in which first generation HMAs are not currently approved.” Hagop Kantarjian, MD, of The University of Texas MD Anderson Cancer Center, the senior author of the study said: “In this study we observed induced clinical responses in heavily pre-treated patients including prior treatment with current HMAs. Buy Apple Cider Vinegar online Together with the results of a large Phase 2 study to be published later, these data support further investigation, including the recently commenced global Phase 3 study in treatment-na"ive AML patients.” About guadecitabine (SGI-110): Guadecitabine is a novel next-generation small molecule, DNA hypomethylating agent designed to be administered as a single, small volume, subcutaneous injection. http://cholesterolreviews.wordpress.com Guadecitabine demonstrated activity in restoring silenced tumor suppressor gene expression in cancer cells by reversal of DNA methylation and inducing responses in previously treated MDS and AML patients. Guadecitabine is wholly owned by Astex Pharmaceuticals. About the SGI-110 study in MDS and AML patients (Study SGI-110-01): The SGI-110-01 trial is a large (over 400 patients) randomized Phase 1/2 study in patients with MDS or AML. The trial included a Phase I dose escalation stage (93 patients) and a randomized Phase 2 stage (308 patients) that investigated four patient populations: treatment na"ive and relapsed / refractory AML and MDS, and also explored both a dailyx5 and a dailyx10 regimen. Additional information about the study can be found online at clinicaltrials.gov/ct2/show/NCT01261312. About the ASTRAL-1 SGI-110 study (Study SGI-110-04) ASTRAL-1 is a large, global, randomized 800-patient study of guadecitabine (SGI-110) in treatment na"ive AML patients who are unfit to receive, or unsuitable for, intensive induction chemotherapy. The trial commenced in March 2015, and compares guadecitabine with physician’s choice of low-dose cytarabine, decitabine or azacitidine. Additional information about the study can be found online at .clinicaltrials.gov/ct2/show/NCT02348489. About Astex Pharmaceuticals Astex Pharmaceuticals is dedicated to the discovery and development of novel small molecule therapeutics with a focus on oncology. Astex is developing a proprietary pipeline of novel therapies and has a number of partnered products being developed under collaborations with leading pharmaceutical companies. In October 2013, Astex was acquired by Otsuka Pharmaceutical Co. Ltd., Tokyo, Japan, and operates as a wholly owned subsidiary. The Otsuka Group employs approximately 43,000 people globally, and its products are available in more than 80 countries worldwide. For more information about Astex Pharmaceuticals, please visit .astx.com For more information about Otsuka Pharmaceutical, please visit .otsuka.com/en/

Partnerships, Licensing, Investments and M&A Deals and Trends for May 2015 in Pharmaceuticals - Analysis of Partnership and Licensing Deals Based on Clinical Stage of Development of Products

. About Doxacard with free Rx DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/c46hn3/partnerships) has announced the addition of the "Partnerships, Licensing, Investments and M&A Deals and Trends for May 2015 in Pharmaceuticals" report to their offering. Partnerships, Licensing, Investments and M&A Deals and Trends for May 2015 in Pharmaceuticals Summary Our Partnerships, Licensing, Investments and M&A Deals and Trends for May 2015 in Pharmaceuticals report is an essential source of data and trend analysis on partnerships, licensing, mergers and acquisitions (M&As) and financings in the pharmaceuticals industry. About Super P-Force (Sildenafil with Dapoxetine) with no prescription Buy Norvasc (Amlodipine) without prescription The report provides detailed information on partnership and licensing transactions, M&As, equity/debt offerings, private equity, and venture financing registered in the pharmaceuticals industry in May 2015. Buy Weight Loss Patches online Buy Isordil (Isosorbide Dinitrate) without prescription The report portrays detailed comparative data on the number of deals and their value in the last six months, subdivided by deal types, various therapy areas, and geographies. http://allergy-opinion.blogspot.com About Serophene (Clomiphene) with no Rx Additionally, the report provides information on the top financial advisory firms in the pharmaceuticals industry. Scope Review of deal trends in the cardiovascular, central nervous system, dermatology, ear nose throat disorders, gastrointestinal, genito urinary system and sex hormones, hematological disorders, hormonal disorders, immunology, infectious disease, male health, metabolic disorders, mouth and dental disorders, musculoskeletal, oncology, ophthalmology, respiratory, toxicology, and women s health segments. Analysis of partnerships, licensing, M&As, equity/debt offerings, private equity, and venture financing deals in the pharmaceutical industry. Analysis of therapy areas which are very active in terms of venture capital financing, partnerships, licensing agreements, equity/debt offerings, and M&As. Key Topics Covered: 1 List of Tables and List of Figures 2 Pharmaceuticals & Healthcare, Global, Deal Summary 3 Pharmaceuticals and Healthcare, Global, Deals, Summary, by Type 4 Pharmaceuticals & Healthcare, Global, Partnership Deals, May 2015 5 Pharmaceuticals & Healthcare, Global, Licensing Agreements, May 2015 6 Pharmaceuticals & Healthcare, Global, Deal Summary by Therapy Area 7 Deal Summary by Geography 8 Pharmaceuticals & Healthcare, Global, Top Financial Advisors 9 Further Information For more information visit .researchandmarkets.com/research/c46hn3/partnerships